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[多纳-兰斯泰纳溶血素。20世纪医学中一个神话的起源]

[The Donath-Landsteiner hemolysin. The origin of a myth in 20th century medicine].

作者信息

Goltz D

出版信息

Clio Med. 1982 Feb;16(4):193-217.

PMID:6189665
Abstract

In the present paper is pointed out that J. Donath and K. L. Landsteiner on no account discovered (as most of modern immunologists are pretending emphatically) the autohemolysin which is still connected with their names; neither can this discovery be attributed to Paul Ehrlich as some modern authors are confirming. The later publications of Donath and Landsteiner following their first famous paper from 1904 which hitherto never was drawn attention to by historians or immunologists clearly demonstrate that both of them thought of a toxin theory in regard to the pathogenesis of paroxysmal cold hemoglobinuria, and yet in 1925 they explicitly denied any kind of immune reaction or autoimmunization being involved in the pathogenesis of this disease. The myth of their supposed discovery was performed by well-known and highly estimated scientists in the field of research in autoimmunity problems based on the psychological well-known motivation to create pioneers and heroes that mark the starting point of their science.

摘要

本文指出,J. 多纳特和K. L. 兰德施泰纳根本没有发现(正如大多数现代免疫学家极力宣称的那样)至今仍与他们名字联系在一起的自身溶血素;这一发现也不能像一些现代作者所证实的那样归功于保罗·埃尔利希。多纳特和兰德施泰纳在1904年发表第一篇著名论文之后的后续出版物,至今从未引起历史学家或免疫学家的关注,这些出版物清楚地表明,他们两人都认为阵发性冷血红蛋白尿的发病机制与毒素理论有关,但在1925年,他们明确否认这种疾病的发病机制涉及任何类型的免疫反应或自身免疫。他们所谓发现的神话是由自身免疫问题研究领域中著名且备受尊敬的科学家制造的,这基于一种广为人知的心理动机,即创造标志着其科学起点的先驱者和英雄。

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Clio Med. 1982 Feb;16(4):193-217.
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