用8-甲氧基补骨脂素和紫外线A光治疗后5-S-半胱氨酰多巴的排泄情况。
5-S-cysteinyldopa excretion after treatment with 8-methoxypsoralen and UVA light.
作者信息
Agrup G, Hansson C, Rorsman H, Rosengren E, Tegner E
出版信息
J Invest Dermatol. 1978 Jan;70(1):25-6. doi: 10.1111/1523-1747.ep12543415.
PMID:618976
Abstract
The excretion of the specific melanocytic metabolite 5-S-cysteinyldopa was studied in patients with psoriasis treated by 8-methoxypsoralen and UVA light. A pronounced increase was found after only 2 days treatment, although no increase in pigmentation could yet be observed. Peak values for urinary 5-S-cysteinyldopa were noted after 1 or 2 weeks treatment. Increase in pigmentation persisted after the excretion maxima for 5-S-cysteinyldopa.
摘要
对接受8-甲氧基补骨脂素和紫外线A光治疗的银屑病患者，研究了特异性黑素细胞代谢产物5-S-半胱氨酰多巴的排泄情况。仅治疗2天后就发现其排泄量显著增加，尽管此时尚未观察到色素沉着增加。治疗1或2周后，尿中5-S-半胱氨酰多巴达到峰值。在5-S-半胱氨酰多巴排泄量达到最大值后，色素沉着仍持续增加。
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