伴有和不伴有循环干扰素的系统性红斑狼疮患者淋巴细胞的体内干扰素诱导2'-5'腺苷酸合成酶及体外干扰素产生
Interferon-induced 2'-5' adenylate synthetase in vivo and interferon production in vitro by lymphocytes from systemic lupus erythematosus patients with and without circulating interferon.
作者信息
Preble O T, Rothko K, Klippel J H, Friedman R M, Johnston M I
出版信息
J Exp Med. 1983 Jun 1;157(6):2140-6. doi: 10.1084/jem.157.6.2140.
Abstract
The interferon (IFN)-induced enzyme 2-5A synthetase was elevated in mononuclear cells from both serum IFN-positive and -negative systemic lupus erythematosus (SLE) patients. This suggests that a much higher percentage of patients than previously thought produce endogenous IFN. These results may partly explain findings that mononuclear cells from SLE patients are deficient in IFN production in vitro in response to certain IFN inducers. Although normal lymphocytes can produce an acid-labile alpha IFN after stimulation with C. parvum in vitro, the reason for endogenous production of this unusual alpha IFN by SLE patients remains unknown.
摘要
干扰素（IFN）诱导酶2-5A合成酶在血清IFN阳性和阴性的系统性红斑狼疮（SLE）患者的单核细胞中均升高。这表明产生内源性IFN的患者比例比之前认为的要高得多。这些结果可能部分解释了以下发现：SLE患者的单核细胞在体外对某些IFN诱导剂的反应中IFN产生不足。虽然正常淋巴细胞在体外受到微小隐孢子虫刺激后可产生酸不稳定的α干扰素，但SLE患者内源性产生这种异常α干扰素的原因仍不清楚。
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