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免疫的人体淋巴细胞产生一种对酸不稳定的α干扰素。

Immune human lymphocytes produce an acid-labile alpha-interferon.

作者信息

Balkwill F R, Griffin D B, Band H A, Beverley P C

出版信息

J Exp Med. 1983 Mar 1;157(3):1059-63. doi: 10.1084/jem.157.3.1059.

DOI:10.1084/jem.157.3.1059
PMID:6403647
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2186960/
Abstract

We have described in this paper a novel human interferon (IFN) with antigenic and cross-species reactivity of alpha-IFN and physicochemical properties of gamma-IFN. This IFN is produced by normal peripheral blood mononuclear cells during an immune response but has also been associated with autoimmune disease (10). The system described here will be useful in elucidating the biological significance and cell of origin of this IFN.

摘要

我们在本文中描述了一种新型人类干扰素（IFN），它具有α-干扰素的抗原性和跨物种反应性以及γ-干扰素的物理化学特性。这种干扰素是在免疫反应期间由正常外周血单核细胞产生的，但也与自身免疫性疾病有关（10）。这里描述的系统将有助于阐明这种干扰素的生物学意义和起源细胞。

相似文献

1
Immune human lymphocytes produce an acid-labile alpha-interferon.免疫的人体淋巴细胞产生一种对酸不稳定的α干扰素。
J Exp Med. 1983 Mar 1;157(3):1059-63. doi: 10.1084/jem.157.3.1059.
2
Human interferon alpha and gamma production by lymphocytes during the generation of influenza virus-specific cytotoxic T lymphocytes.流感病毒特异性细胞毒性T淋巴细胞产生过程中淋巴细胞产生人干扰素α和γ 。
J Gen Virol. 1986 Nov;67 ( Pt 11):2325-34. doi: 10.1099/0022-1317-67-11-2325.
3
Immune interferon produced to high levels by antigenic stimulation of human lymphocytes with influenza virus.通过用流感病毒对抗人淋巴细胞进行抗原刺激可产生高水平的免疫干扰素。
J Exp Med. 1981 Nov 1;154(5):1279-89. doi: 10.1084/jem.154.5.1279.
4
Acid-labile human interferon alpha production by peripheral blood mononuclear cells stimulated by HIV-infected cells.由HIV感染细胞刺激外周血单个核细胞产生酸不稳定的人α干扰素
Arch Virol. 1988;99(1-2):9-19. doi: 10.1007/BF01311019.
5
Spontaneous production of interferon-gamma and acid-labile interferon-alpha by subpopulations of human mononuclear cells.人单核细胞亚群自发产生γ干扰素和酸不稳定α干扰素。
Cell Immunol. 1983 Oct 15;81(2):426-34. doi: 10.1016/0008-8749(83)90249-6.
6
Vaccine-Induced Antibody Responses Prevent the Induction of Interferon Type I Responses Upon a Homotypic Live Virus Challenge.疫苗诱导的抗体反应可防止在同型活病毒攻击时诱导I型干扰素反应。
Scand J Immunol. 2016 Mar;83(3):165-73. doi: 10.1111/sji.12410.
7
[Formation of an acid-labile interferon induced in human leukocytes by the influenza virus].[流感病毒诱导人白细胞产生的酸不稳定干扰素的形成]
Vopr Virusol. 1987 Jan-Feb;32(1):96-9.
8
[Acid-labile alpha interferon produced by peripheral blood mononuclear cells stimulated by cells infected by HIV].[由感染HIV的细胞刺激外周血单个核细胞产生的酸不稳定α干扰素]
Ann Ig. 1989 May-Aug;1(3-4):647-60.
9
Release of discrete interferons by cytotoxic T lymphocytes in response to immune and nonimmune stimuli.细胞毒性T淋巴细胞在对免疫和非免疫刺激作出反应时释放离散干扰素。
J Immunol. 1984 Jul;133(1):277-80.
10
Induction of interferon alpha and gamma from human lymphocytes by dengue virus-infected cells.登革病毒感染的细胞诱导人淋巴细胞产生α和γ干扰素。
J Gen Virol. 1986 Aug;67 ( Pt 8):1653-61. doi: 10.1099/0022-1317-67-8-1653.

引用本文的文献

1
Interferon-gamma production by peripheral blood mononuclear cells from patients with Behçet's syndrome.白塞病患者外周血单个核细胞产生干扰素-γ的情况。
Clin Exp Immunol. 1984 Sep;57(3):541-7.
2
Interferon-induced 2'-5' adenylate synthetase in vivo and interferon production in vitro by lymphocytes from systemic lupus erythematosus patients with and without circulating interferon.伴有和不伴有循环干扰素的系统性红斑狼疮患者淋巴细胞的体内干扰素诱导2'-5'腺苷酸合成酶及体外干扰素产生
J Exp Med. 1983 Jun 1;157(6):2140-6. doi: 10.1084/jem.157.6.2140.
3
Interferons, a group of multiple lymphokines.干扰素，一组多种淋巴因子。
Springer Semin Immunopathol. 1984;7(4):347-74. doi: 10.1007/BF00201966.
4
Control of immune interferon release by cytotoxic T-cell clones specific for influenza.流感特异性细胞毒性T细胞克隆对免疫干扰素释放的控制
Immunology. 1985 Apr;54(4):607-14.
5
Serum levels of interferons in patients with systemic lupus erythematosus.系统性红斑狼疮患者的血清干扰素水平。
Clin Exp Immunol. 1987 Dec;70(3):562-9.

本文引用的文献

1
Interferon-Like Virus-Inhibitor Induced in Human Leukocytes by Phytohemagglutinin.植物血球凝集素诱导人白细胞产生干扰素样病毒抑制剂。
Science. 1965 Jul 16;149(3681):310-1. doi: 10.1126/science.149.3681.310.
2
Analysis and purification of human lymphoblastoid (Namalwa) interferon using a monoclonal antibody.使用单克隆抗体对人淋巴母细胞样（Namalwa）干扰素进行分析与纯化。
J Gen Virol. 1982 Nov;63 (Pt 1):207-12. doi: 10.1099/0022-1317-63-1-207.
3
Long-term human T-helper lines producing specific helper factor reactive to influenza virus.产生对流感病毒有反应的特异性辅助因子的长期人类T辅助细胞系。
Nature. 1981 Nov 12;294(5837):166-8. doi: 10.1038/294166a0.
4
Heterogeneity of human gamma interferon preparations: evidence for presence of alpha interferon.人γ干扰素制剂的异质性：α干扰素存在的证据。
J Interferon Res. 1981 Feb;1(2):315-21. doi: 10.1089/jir.1981.1.315.
5
Determination of human leukocyte populations involved in production of interferons alpha and gamma.参与α和γ干扰素产生的人白细胞群体的测定。
J Interferon Res. 1981 Feb;1(2):233-44. doi: 10.1089/jir.1981.1.233.
6
Production of immune interferon by human cytotoxic T cell clones.人细胞毒性T细胞克隆产生免疫干扰素。
J Immunol. 1982 Aug;129(2):450-1.
7
Systemic lupus erythematosus: presence in human serum of an unusual acid-labile leukocyte interferon.系统性红斑狼疮：人血清中存在一种异常的酸不稳定白细胞干扰素。
Science. 1982 Apr 23;216(4544):429-31. doi: 10.1126/science.6176024.
8
Antigen-specific production of immune interferon by T Cells lines.T细胞系对抗原特异性产生免疫干扰素。
J Exp Med. 1982 Apr 1;155(4):1204-9. doi: 10.1084/jem.155.4.1204.
9
Immune interferon produced to high levels by antigenic stimulation of human lymphocytes with influenza virus.通过用流感病毒对抗人淋巴细胞进行抗原刺激可产生高水平的免疫干扰素。
J Exp Med. 1981 Nov 1;154(5):1279-89. doi: 10.1084/jem.154.5.1279.
10
Biological characteristics of cell line GL-V3 derived from the kidney of a vervet monkey (Cercopithecus aethiops).源自绿猴（非洲长尾猴）肾脏的细胞系GL-V3的生物学特性。
J Med Microbiol. 1970 May;3(2):251-8. doi: 10.1099/00222615-3-2-251.