Schachenmayr W, Friede R L
J Neuropathol Exp Neurol. 1978 Jan;37(1):34-44. doi: 10.1097/00005072-197801000-00003.
In a case of hypertrophy of the pyramidal tract the cross section of the hypertrophic pyramids was 174% of controls with an increase (148%) in the total population of myelinated fibers. However, there was no commensurate increase in the density of Betz cells. Confined to the hypertrophic tract there was a peculiar anomaly consisting of tubes of thick myelin sheaths that encompassed columns of glial nuclei instead of axons. This type of change, along with the clinical data, may indicate that the lesion originated in the perinatal period when myelin formation is in progress and is susceptible to derangement.
在一例锥体束肥大的病例中，肥大锥体的横截面积是对照组的174%，有髓纤维总数增加了（148%）。然而，贝茨细胞的密度并没有相应增加。在肥大的束内存在一种特殊异常，由厚髓鞘管组成，这些髓鞘管包围着胶质细胞核柱而非轴突。这种类型的变化，连同临床数据，可能表明病变起源于围生期，此时髓鞘正在形成且易受紊乱影响。
