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研究进展：通过提高细胞内环磷酸腺苷水平对人乳腺癌细胞进行辐射防护

Work in progress: radioprotection of human breast cancer cells by elevation of intracellular cyclic AMP.

作者信息

Griem K, Weichselbaum R R, Umans R S, Gifford L, Little J B

出版信息

Radiology. 1983 Jul;148(1):289-90. doi: 10.1148/radiology.148.1.6190195.

DOI:10.1148/radiology.148.1.6190195
PMID:6190195
Abstract

MCF-7 human breast cancer cells that were treated for one hour prior to X irradiation with the cyclic AMP-inducing agent 1-methyl-3-isobutylxanthine displayed a slight but significant increase in surviving fraction over untreated controls at each radiation dose level. This was accompanied by a two-fold increase in the level of intracellular cyclic AMP.

摘要

在用环磷酸腺苷诱导剂1-甲基-3-异丁基黄嘌呤在X射线照射前处理1小时的MCF-7人乳腺癌细胞中，在每个辐射剂量水平下，其存活分数相对于未处理的对照有轻微但显著的增加。这伴随着细胞内环磷酸腺苷水平增加了两倍。

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1
Work in progress: radioprotection of human breast cancer cells by elevation of intracellular cyclic AMP.研究进展：通过提高细胞内环磷酸腺苷水平对人乳腺癌细胞进行辐射防护
Radiology. 1983 Jul;148(1):289-90. doi: 10.1148/radiology.148.1.6190195.
2
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