Wagner F C, VanGilder J C, Dohrmann G J
J Neurosurg. 1978 Jan;48(1):92-8. doi: 10.3171/jns.1978.48.1.0092.
The pathological changes occurring in the thoracic spinal cords of 41 cats were studied by light microscopy at 4 hours, 4 weeks, and 4 months after graded transdural trauma. Alterations characteristic of a vascular injury proportionate to the magnitude of the original trauma which results in tissue hypoxia, destruction, and reparation were identified at each interval studied. In more severely injured animals these changes consisted of an initial hemorrhagic infarction followed by the removal of necrotic parenchyma and the development of an adhesive arachnoiditis and intramedullary carvitation. A comparison of the findings in the present investigation with what has been described in postmortem studies of spinal cord injured patients indicates that the response of the spinal cord to non-disruptive trauma is similar in both cases.
在41只猫的胸段脊髓上，于分级经硬脊膜创伤后4小时、4周和4个月，通过光学显微镜研究了其病理变化。在每个研究间隔期，均发现了与原始创伤程度成比例的血管损伤特征性改变，这些改变导致组织缺氧、破坏和修复。在损伤更严重的动物中，这些变化包括最初的出血性梗死，随后是坏死实质的清除以及粘连性蛛网膜炎和髓内空洞形成。将本研究结果与脊髓损伤患者尸检研究中所描述的情况进行比较表明，脊髓对非破坏性创伤的反应在两种情况下是相似的。
