Metabolism of asialoglycoproteins in cultured rat hepatocytes: evidence for receptor mediated uptake and degradation which is not feed-back regulated.
作者信息
Drevon C A, Tolleshaug H, Carlander B, Berg T
出版信息
Int J Biochem. 1983;15(6):827-33. doi: 10.1016/0020-711x(83)90154-4.
PMID:6190689
Abstract
- Cultured rat hepatocytes took up and degraded asialofetuin by a saturable mechanism. 2. The uptake was specific for desialylated fetuin; native fetuin and was taken up to a much lesser extent. 3. Degradation was inhibited by lysosomotropic agents; both uptake and degradation were, however, unaffected by cycloheximide. 4. The uptake was also unaffected by incubating the cells for 24 hr in the presence of large extracellular concentrations of unlabelled asialofetuin. 5. The data suggest that the asialoglycoprotein receptor is recycled and not subject to down-regulation.
摘要
相似文献
1
Metabolism of asialoglycoproteins in cultured rat hepatocytes: evidence for receptor mediated uptake and degradation which is not feed-back regulated.
Int J Biochem. 1983;15(6):827-33. doi: 10.1016/0020-711x(83)90154-4.
2
Effects of lysosomal inhibitors on 125I-insulin and 125I-asialofetuin degradation by the isolated, perfused rat liver and isolated rat hepatocytes.
Diabetes. 1985 May;34(5):446-51. doi: 10.2337/diab.34.5.446.
3
Binding and internalization of asialo-glycoproteins by isolated rat hepatocytes.
Int J Biochem. 1981;13(1):45-51. doi: 10.1016/0020-711x(81)90135-x.
4
Uptake and degradation of desialylated luteinizing hormone by suspended hepatocytes.
Biochim Biophys Acta. 1982 Apr 29;720(2):193-202. doi: 10.1016/0167-4889(82)90012-x.
5
Degradation of endogenous proteins and internalized asialofetuin in primary cultured hepatocytes of rats.
Int J Biochem. 1989;21(5):483-95. doi: 10.1016/0020-711x(89)90128-6.
6
The effects of ammonium ions and chloroquine on uptake and degradation of 125I-labeled asialo-fetuin in isolated rat hepatocytes.
Biochem Pharmacol. 1980 Mar 15;29(6):917-25. doi: 10.1016/0006-2952(80)90222-1.
7
Uptake, intracellular transport, and degradation of polyethylene glycol-modified asialofetuin in hepatocytes.
J Biol Chem. 1992 Nov 15;267(32):22987-93.
8
Metabolism of asialotranscortin by hepatocytes and cortisol binding to hepatocytes.
Endocr Res Commun. 1981;8(2):111-25. doi: 10.1080/07435808109049842.
9
Intracellular segregation of asialo-transferrin and asialo-fetuin following uptake by the same receptor system in suspended hepatocytes.
Biochim Biophys Acta. 1984 Mar 23;803(3):182-90. doi: 10.1016/0167-4889(84)90008-9.
10
Monensin inhibits receptor-mediated endocytosis of asialoglycoproteins in rat hepatocytes.
Exp Cell Res. 1983 Oct 15;148(2):319-30. doi: 10.1016/0014-4827(83)90156-8.
引用本文的文献
1
The effects of monensin on secretion of very-low-density lipoprotein and metabolism of asialofetuin by cultured rat hepatocytes.
Biochem J. 1985 Apr 15;227(2):529-36. doi: 10.1042/bj2270529.
2
Recognition of chylomicron remnants and beta-migrating very-low-density lipoproteins by the remnant receptor of parenchymal liver cells is distinct from the liver alpha 2-macroglobulin-recognition site.
Biochem J. 1991 Nov 1;279 ( Pt 3)(Pt 3):863-70. doi: 10.1042/bj2790863.
Zotero 插件