Kuhn J M, Rieu M, Rochette J, Krishnamoorthy R, Labie D, Elion J, Luton J P, Bricaire H
J Clin Endocrinol Metab. 1983 Aug;57(2):344-8. doi: 10.1210/jcem-57-2-344.
We studied the electrophoretic pattern of hemoglobin (Hb) and red blood cell indices in 128 women divided into four groups: group I, 36 nonanemic hyperthyroid women, divided in two subgroups: 36 with untreated hyperthyroidism (subgroup IA) and 9 made euthyroid by antithyroid drug therapy (subgroup IB); group II, 12 nonanemic women with untreated hypothyroidism; group III, 30 women known to be heterozygous for beta-thalassemia; and group IV, 50 healthy women. The mean (+/- SEM) HbA2 level was higher (P less than 0.001) in subgroup IA (3.21 +/- 0.06%) than in subgroup IB (2.42 +/- 0.09%) and group IV (2.48 +/- 0.04%), but lower (P less than 0.001) than in group III (5.26 +/- 0.12%). The mean HbA2 level was lower (P less than 0.001) in group II (1.99 +/- 0.08%) than in group IV. Hb fetal was detectable in eight patients of subgroup IA and undetectable in subgroup IB and groups II and IV. The mean cellular volume was lower (P less than 0.001) in subgroup IA than in other nonanemic groups. The mean cellular volume was higher (P less than 0.001) in group II than in group IV. Follow-up of nine patients who became euthyroid with treatment showed the normalization of these erythrocyte parameters. These results suggest that thyroid hormones can modulate the synthesis of delta- and gamma-globin chains.
我们研究了128名女性的血红蛋白（Hb）电泳模式和红细胞指数，这些女性被分为四组：第一组，36名非贫血性甲状腺功能亢进女性，分为两个亚组：36名未经治疗的甲状腺功能亢进患者（亚组IA）和9名通过抗甲状腺药物治疗变为甲状腺功能正常的患者（亚组IB）；第二组，12名未经治疗的甲状腺功能减退的非贫血女性；第三组，30名已知为β地中海贫血杂合子的女性；第四组，50名健康女性。亚组IA（3.21±0.06%）的平均（±标准误）HbA2水平高于亚组IB（2.42±0.09%）和第四组（2.48±0.04%）（P<0.001），但低于第三组（5.26±0.12%）（P<0.001）。第二组（1.99±0.08%）的平均HbA2水平低于第四组（P<0.001）。亚组IA的8名患者可检测到胎儿血红蛋白，而亚组IB、第二组和第四组未检测到。亚组IA的平均细胞体积低于其他非贫血组（P<0.001）。第二组的平均细胞体积高于第四组（P<0.001）。对9名经治疗后变为甲状腺功能正常的患者进行随访，结果显示这些红细胞参数恢复正常。这些结果表明，甲状腺激素可以调节δ和γ珠蛋白链的合成。
