Oie S, Levy G
J Pharm Sci. 1978 Jan;67(1):45-7. doi: 10.1002/jps.2600670112.
The intrinsic body clearance of bilirubin was determined in 48 adult male Sprague--Dawley rats that received an intravenous infusion of bilirubin. The intrinsic body clearance was calculated from the infusion rate, the steady-state plasma concentration of total (free and protein-bound) bilirubin, and the free fraction of bilirubin in plasma. The intrinsic body clearance of bilirubin ranged from 5.05 to 13.20 liters/kg/min and was bimodally distributed, with half of the animals in each group. The plasma free fraction of bilirubin ranged from 0.00025 to 0.00077 (mean 0.00053) in the 24 intrinsically rapid metabolizers of bilirubin and from 0.00048 to 0.00103 (mean 0.00075) in the intrinsically slow metabolizers of the pigment. Thus, interindividual differences in the total clearance of bilirubin in the rats are due to differences in both intrinsic body clearance and plasma protein binding.
在48只接受胆红素静脉输注的成年雄性斯普拉格-道利大鼠中测定了胆红素的体内固有清除率。体内固有清除率是根据输注速率、总胆红素（游离胆红素和结合胆红素）的稳态血浆浓度以及血浆中胆红素的游离分数计算得出的。胆红素的体内固有清除率范围为5.05至13.20升/千克/分钟，呈双峰分布，每组各有一半的动物。在24只胆红素固有快速代谢者中，血浆胆红素游离分数范围为0.00025至0.00077（平均0.00053），在色素固有缓慢代谢者中为0.00048至0.00103（平均0.00075）。因此，大鼠中胆红素总清除率的个体差异是由于体内固有清除率和血浆蛋白结合的差异所致。
