Chiang C W, Fuller G C, Frankenfeld J W, Rhodes C T
J Pharm Sci. 1978 Jan;67(1):63-6. doi: 10.1002/jps.2600670117.
The in vitro removal of six barbiturates from pH 2 donor solutions by liquid membranes with pH control was evaluated. More than 90% of amorbarbital, phenobarbital, and secobarbital were removed within 10 min by the liquid membranes. Drug transport obeyed first-order kinetics initially, and Fick's law was obeyed. The transport rate of phenobarbital by a liquid membrane was temperature dependent. An Arrhenius plot revealed that the activation energy was 10 kcal/mole. The liquid membranes showed some instability in the presence of bile salts.
评估了通过具有pH控制的液膜从pH 2供体溶液中体外去除六种巴比妥类药物的情况。在10分钟内，液膜去除了超过90%的异戊巴比妥、苯巴比妥和司可巴比妥。药物转运最初遵循一级动力学，并且符合菲克定律。液膜对苯巴比妥的转运速率与温度有关。阿累尼乌斯图显示活化能为10千卡/摩尔。在胆盐存在下，液膜表现出一定的不稳定性。
