染色单体畸变形成的交换假说：使用博来霉素的实验检验

The exchange hypothesis for the formation of chromatid aberrations: an experimental test using bleomycin.

作者信息

Duncan A M, Evans H J

出版信息

Mutat Res. 1983 Feb;107(2):307-13. doi: 10.1016/0027-5107(83)90172-0.

PMID:6191213

Abstract

The association between bleomycin-induced chromatid aberrations and BUdR-label exchange between sister chromatids was investigated in order to evaluate Revell's exchange hypothesis for the formation of chromatid aberrations. The results of this study indicate that a larger than expected proportion of chromatid breaks can be accounted for by the exchange hypothesis though not all breaks are the result of incomplete exchange.

摘要

为了评估雷维尔关于染色单体畸变形成的交换假说，研究了博来霉素诱导的染色单体畸变与姐妹染色单体之间5-溴脱氧尿苷（BUdR）标记交换之间的关联。这项研究的结果表明，尽管并非所有的断裂都是不完全交换的结果，但交换假说可以解释比预期更大比例的染色单体断裂。