Valente E J, Trager W F
J Med Chem. 1978 Jan;21(1):141-3. doi: 10.1021/jm00199a031.
The configurationally similar enantiomers of warfarin and phenprocoumon are found to exhibit circular dichroism curves which are nearly mirror related in the range of 240-340 nm. This effect is interpreted as being due to spatial similarities of the preferred conformations of opposite configurations of the two drugs in solution. An inherently dissymmetric chromophore (theta approximately 1.2 x 10(5)) is observed at approximately 220 nm for warfarin, the cyclic hemiketal tautomeric forms, and the cyclic methyl ketals.
华法林和苯丙香豆素的构型相似对映体在240 - 340纳米范围内呈现出近乎镜像相关的圆二色性曲线。这种效应被解释为是由于两种药物在溶液中相反构型的优选构象在空间上的相似性。对于华法林、环状半缩酮互变异构体和环状甲基缩酮，在约220纳米处观察到一个固有不对称发色团（θ约为1.2×10⁵）。
