Borel Y, Takaoki M, Cookson E, Greene M I
Clin Immunol Immunopathol. 1983 Jan;26(1):35-46. doi: 10.1016/0090-1229(83)90171-x.
Cellular immune responses against nucleic acid antigens were analyzed in BALB/C mice. Delayed-type hypersensitivity (DTH) could be elicited by immunizing and challenging with either guanosine-coupled spleen cells (G-SC) or adenosine-coupled spleen cells (A-SC), and measured by footpad swellings. The epitope density was critical for immunization. This cellular reaction was specific to nucleosides, and cross-immunity was observed between A-SC and G-SC. In addition, cross-unresponsiveness was observed between these two nucleosides. In contrast, soluble carrier proteins coupled with either guanosine or adenosine did not induce cross-reactive immunity or unresponsiveness. The significance of the difference between these two forms of antigens in the ability to induce cross-reactivity is discussed in the context of T versus B-cell recognition in the induction or the expression of the immune response.
在BALB/C小鼠中分析了针对核酸抗原的细胞免疫反应。通过用鸟苷偶联的脾细胞（G-SC）或腺苷偶联的脾细胞（A-SC）进行免疫和激发，可引发迟发型超敏反应（DTH），并通过足垫肿胀来测量。表位密度对免疫至关重要。这种细胞反应对核苷具有特异性，并且在A-SC和G-SC之间观察到交叉免疫。此外，在这两种核苷之间观察到交叉无反应性。相比之下，与鸟苷或腺苷偶联的可溶性载体蛋白不会诱导交叉反应性免疫或无反应性。在免疫反应的诱导或表达中，在T细胞与B细胞识别的背景下讨论了这两种抗原形式在诱导交叉反应性能力方面差异的意义。
