Kawagoe K, Iijima S, Tsunoda H, Sasaki J, Inaba J
Nihon Sanka Fujinka Gakkai Zasshi. 1983 Jun;35(6):787-95.
Five cases of recurrent cervical carcinoma with restricted recurrent site in the pelvis were treated with intra-arterial infusion of oncostatics via the internal iliac artery. The tip of the catheter was put in the internal iliac artery, just proximal to the superior glutea artery, through the a. glutea inferior or superior with ligation of both the a. glutea superior and inferior so as to get a high concentration of drugs at the lesion. Several chemotherapeutic agents, such as Cisplatin, adriamycin, pepleomycin, mitomycin C and 5-FU, were infused through the other end of the catheter, which was fixed at the subclavian fossa of the anterior chest. The clinical efficacies according to Karnofsky's criteria were 0-C in one case, 1-A in 1 case and 1-B in 3 cases. The overall response rate above 1-B was 60%. Two cases were dead, one due to inflammation in the pelvic dead space and D.I.C. and other due to myocarditis and heart failure. The other three were alive and treated with weekly intra-arterial infusion at our outpatient clinic. No troubles, such as spontaneous removal of the catheter, inflammation around the catheter or bleeding, have been encountered. The toxicities in the case of intra-arterial infusion were less prominent than in the case of intravenous administration of the same dosage of the oncostatics.
对5例盆腔内复发部位受限的复发性宫颈癌患者，经髂内动脉进行抗癌药物动脉内灌注治疗。通过臀下动脉或臀上动脉将导管尖端置于髂内动脉，恰好在臀上动脉近端，同时结扎臀上动脉和臀下动脉，以便在病变部位获得高浓度药物。通过固定在前胸锁骨下窝处的导管另一端，注入几种化疗药物，如顺铂、阿霉素、平阳霉素、丝裂霉素C和5-氟尿嘧啶。根据卡诺夫斯基标准，临床疗效为：1例0-C，1例1-A，3例1-B。高于1-B的总有效率为60%。2例死亡，1例死于盆腔死腔炎症和弥散性血管内凝血，另1例死于心肌炎和心力衰竭。另外3例存活，在我们门诊接受每周一次的动脉内灌注治疗。未出现诸如导管自行脱落、导管周围炎症或出血等问题。动脉内灌注情况下的毒性比相同剂量抗癌药物静脉给药时轻。
