Hedlund H, Andersson K E, Ek A
J Urol. 1983 Aug;130(2):275-8. doi: 10.1016/s0022-5347(17)51106-4.
Prazosin, a selective alpha-1-adrenoceptor blocker, was used in a double-blind crossover study in 20 men with benign prostatic obstruction. Maximum and average flow rates increased, and residual volume and obstructive symptoms were reduced. Voiding pressure parameters, bladder capacity and irritative symptoms did not change significantly. No side effects were noted. We conclude that prazosin seems to be an effective therapeutic alternative in patients with benign prostatic obstruction.
哌唑嗪，一种选择性α-1肾上腺素能受体阻滞剂，在一项针对20名良性前列腺梗阻男性患者的双盲交叉研究中被使用。最大尿流率和平均尿流率增加，残余尿量和梗阻症状减轻。排尿压力参数、膀胱容量和刺激症状没有明显变化。未观察到副作用。我们得出结论，哌唑嗪似乎是良性前列腺梗阻患者的一种有效治疗选择。
