大多数对干扰素诱导特异性序列有强阳性信号的cDNA克隆类似于线粒体核糖体RNA基因。

The majority of cDNA clones with strong positive signals for the interferon-induction-specific sequences resemble mitochondrial ribosomal RNA genes.

作者信息

Tsuzuki T, Nomiyama H, Setoyama C, Maeda S, Shimada K, Pestka S

出版信息

Biochem Biophys Res Commun. 1983 Jul 29;114(2):670-6. doi: 10.1016/0006-291x(83)90833-1.

PMID:6192820

Abstract

A complementary DNA library prepared from the 12S polyadenylated RNAs extracted from interferon-induced KG-1 cells, a human myeloblast cell line, was screened for the presence of induction-specific sequences. Clones that exhibited strong positive signals were separated by hybridization criteria into nine classes. Clones from classes I through IV consisted of about 78% of the total and unexpectedly were found to resemble human mitochondrial ribosomal RNA genes.

摘要

从干扰素诱导的KG-1细胞（一种人成髓细胞系）提取的12S聚腺苷酸化RNA制备的互补DNA文库，被筛选以寻找诱导特异性序列。通过杂交标准将显示强阳性信号的克隆分为九类。I至IV类的克隆约占总数的78%，出乎意料的是，发现它们与人线粒体核糖体RNA基因相似。