Goldzieher J W, Villegas-Castrejon H, Cervantes A, Maqueo M, Siperstein M D
Obstet Gynecol. 1978 Jan;51(1):89-92.
The possible vascular hazard associated with carbohydrate intolerance produced by long-term use of oral contraceptives was investigated by examining the capillary basement membrane thickness in quadriceps muscle biopsies, a highly sensitive and reliable indicator of diabetic microangiopathy. The average basement thickness of 18 long-term (4-9 years) contraceptive users with diminished carbohydrate tolerance was 1644 A, compared to normal pregnant women (1711 A) prediabetic pregnant women (1854 A), and overt diabetic women (2593 A). Contraceptive steroid-induced carbohydrate intolerance appears to carry little, if any, increased risk for the development of diabetic vascular disease, even as assessed by the sensitive electron microscopic technique.
通过检测股四头肌活检组织中毛细血管基底膜厚度，对长期使用口服避孕药导致的碳水化合物不耐受可能带来的血管危害进行了研究，该指标是糖尿病微血管病变高度敏感且可靠的指标。18名长期（4 - 9年）使用避孕药且碳水化合物耐量降低的使用者的平均基底膜厚度为1644埃，与之相比，正常孕妇为1711埃，糖尿病前期孕妇为1854埃，显性糖尿病女性为2593埃。即使通过敏感的电子显微镜技术评估，避孕药类固醇导致的碳水化合物不耐受似乎也几乎不会增加患糖尿病血管疾病的风险，即便有风险也是极小的。
