Léger J M, Sauron B, Rousseaux P, Gray F
Rev Neurol (Paris). 1983;139(5):375-9.
A 58 year-old man developed a progressive encephalopathy four years after Whipple's disease onset with digestive, lymph node, and multiple joint lesions, treated over a period of two years. The diagnosis of neurological manifestations of Whipple's disease was based on clinical findings and the presence of PAS+ inclusion bodies in CSF cells. The outcome was fatal in spite of antibiotic therapy. Diagnostic features of this rare neurological affection are discussed. Preventive treatment and surveillance of patients with Whipple's disease are necessary even after well-conducted therapy.
一名58岁男性在惠普尔病发病四年后出现进行性脑病，伴有消化系统、淋巴结和多关节病变，病程长达两年。惠普尔病神经表现的诊断基于临床发现以及脑脊液细胞中存在PAS阳性包涵体。尽管进行了抗生素治疗，结果仍为致命。本文讨论了这种罕见神经疾病的诊断特征。即使在进行了充分治疗后，对惠普尔病患者进行预防性治疗和监测也是必要的。
