Chalès G, Fauchet R, Pawlotsky Y, Gueguen M, Coutard J, Duval A, Pittie P
Rev Rhum Mal Osteoartic. 1983 Jun;50(7):525-31.
The authors present a study of the incidence of HLA-DR antigens in 113 controls and in a Breton population suffering from chronic inflammatory rheumatism. They found 80 cases of rheumatoid arthritis and found a significant increase incidence of the DR4 antigen in rheumatoid arthritis (54% compared with 19.5%; pc less than 10(-4); RR = 4.8) and a decreased incidence of the DR2 antigen (12.5% compared with 35%; pc less than 10(-2); RR = 0.27). The increased incidence of DR4 does not seem to be related to the presence of rheumatoid factor. Out of the 95 cases of chronic inflammatory rheumatism treated, 33 cases of drug intolerance (cutaneous and/or renal to gold salts or D-penicillamine) were reported. The authors found a decreased incidence of the DR2 antigen in the patients who presented a drug intolerance, which was partially significant in the group of patients with rheumatoid arthritis (p less than 0.04; pc less than 0.3). This is an important argument in favour of the supposed protective role of this antigen.
作者对113名对照者以及布列塔尼患有慢性炎性风湿病的人群进行了HLA - DR抗原发生率的研究。他们发现80例类风湿性关节炎患者，且发现类风湿性关节炎中DR4抗原的发生率显著增加（54% 对比19.5%；P值小于10⁻⁴；相对危险度RR = 4.8），而DR2抗原的发生率降低（12.5% 对比35%；P值小于10⁻²；RR = 0.27）。DR4发生率的增加似乎与类风湿因子的存在无关。在接受治疗的95例慢性炎性风湿病患者中，报告了33例药物不耐受情况（对金盐或青霉胺的皮肤和/或肾脏不耐受）。作者发现出现药物不耐受的患者中DR2抗原的发生率降低，这在类风湿性关节炎患者组中部分具有显著性（P小于0.04；P值小于0.3）。这是支持该抗原假定保护作用的一个重要论据。
