Gladman D D, Anhorn K A
J Rheumatol. 1986 Apr;13(2):274-6.
Forty-eight Canadian patients with rheumatoid arthritis (RA) were tissue typed for class 1 (HLA-A, B, and C) and class 2 (HLA-DR and DQ) antigens in an attempt to identify HLA associations and to relate them to disease manifestations and drug toxicity. HLA-DR4 was found with a significantly higher frequency among patients with RA than in the control population. DR4 correlated with presence of rheumatoid nodules and pulmonary manifestations, and was more frequent among patients who had vasculitis. All 4 patients who died were DR4 positive. DR2 and DR7 were less frequent in our patients. There was no association between the presence of DR3 or DR4 and drug toxicity.
对48名加拿大类风湿性关节炎（RA）患者进行了I类（HLA - A、B和C）和II类（HLA - DR和DQ）抗原的组织分型，以试图确定HLA相关性，并将其与疾病表现和药物毒性联系起来。发现RA患者中HLA - DR4的频率显著高于对照组人群。DR4与类风湿结节和肺部表现的存在相关，并且在患有血管炎的患者中更常见。所有4名死亡患者均为DR4阳性。DR2和DR7在我们的患者中频率较低。DR3或DR4的存在与药物毒性之间没有关联。
