Greenblatt D J, Harmatz J S, Shader R I
Pharmacology. 1978;16(1):26-9. doi: 10.1159/000136742.
Sex differences in the extent of binding of diazepam to plasma protein were assessed in a series of patients with renal insufficiency previously described by Kangas et al. Among identifiable independent variables, sex alone accounted for the greatest proportion of variability in percent unbound diazepam (r = 0.33), whereas age and serum creatinine accounted for practically none. The mean (+/- SE) percent unbound among females (10.8 +/- 2.8%) was larger (p less than 0.1) than among males (5.8 +/- 1.3%). Since only the unbound fraction of diazepam in plasma is available for pharmacologic activity, the intensity and duration of diazepam's clinical action in patients with renal insufficiency might differ between males and females.
在Kangas等人之前描述的一系列肾功能不全患者中，评估了地西泮与血浆蛋白结合程度的性别差异。在可识别的独立变量中，仅性别就占未结合地西泮百分比变异性的最大比例（r = 0.33），而年龄和血清肌酐几乎没有影响。女性中未结合的平均（±标准误）百分比（10.8±2.8%）高于男性（5.8±1.3%）（p<0.1）。由于只有血浆中未结合的地西泮部分具有药理活性，因此肾功能不全患者中地西泮临床作用的强度和持续时间在男性和女性之间可能存在差异。
