Ozawa M, Higaki K, Kawata M, Sekiya S, Takamizawa H, Okumura K, Muramatsu T
Biochem Biophys Res Commun. 1983 Aug 30;115(1):268-74. doi: 10.1016/0006-291x(83)90999-3.
Certain patients with ovarian germ cell tumors develop a specific antibody reacting with glycoprotein-bound large carbohydrates of murine teratocarcinoma cells. The antigenic determinant was found to involve an alpha-galactosyl residue, since alpha-galactosidase from coffee bean, but not other glycosidases abolished the antigenic activity of the large glycan isolated from F9 and OTT6050 cells. Several evidences excluded the possibility that the antigen is blood group B or P1 antigen. These results indicate tumor-associated expression of an unusual alpha-galactosyl residue in human ovarian germ cell tumors.
某些卵巢生殖细胞肿瘤患者会产生一种特异性抗体，该抗体可与鼠畸胎瘤细胞中糖蛋白结合的大碳水化合物发生反应。已发现抗原决定簇涉及一个α-半乳糖基残基，因为咖啡豆中的α-半乳糖苷酶可消除从F9和OTT6050细胞中分离出的大聚糖的抗原活性，而其他糖苷酶则不能。多项证据排除了该抗原是B血型或P1抗原的可能性。这些结果表明，人卵巢生殖细胞肿瘤中存在一种异常α-半乳糖基残基的肿瘤相关表达。
