Alonso G, Assenmacher I
Cell Tissue Res. 1983;233(1):183-96. doi: 10.1007/BF00222242.
The axonal transport of neurosecretory material was studied in neurosecretory axons of the supraoptico-posthypophyseal system after in-situ transection of the median eminence. Two hours, 8 h, and 18 h after the lesion, both vasopressin and oxytocin antibodies revealed progressive accumulations of immunoreactive material not only in the proximal but also in the distal stumps of the transected axons. The electron-microscopic examination of these axonal portions revealed that such intense immunopositive labelings could be correlated, in both stumps, to a conspicuous accumulation of neurosecretory granules. It is concluded that, under normal physiological conditions, a significant amount of axoplasmic neurosecretory material is transported in retrograde direction and that such a retrograde transport mainly involves neurosecretory granules.
在正中隆起原位横断后，对视上核 - 垂体后叶系统神经分泌轴突中的神经分泌物质的轴突运输进行了研究。损伤后2小时、8小时和18小时，抗血管加压素和抗催产素抗体均显示，免疫反应性物质不仅在横断轴突的近端残端，而且在远端残端都有逐渐积累。对这些轴突部分的电子显微镜检查显示，在两个残端中，如此强烈的免疫阳性标记都与神经分泌颗粒的明显积累相关。得出的结论是，在正常生理条件下，大量轴浆神经分泌物质沿逆行方向运输，并且这种逆行运输主要涉及神经分泌颗粒。
