Peterson A, Marler J
Neurosci Lett. 1983 Jul 29;38(2):163-8. doi: 10.1016/0304-3940(83)90034-4.
The myelin basic protein (P1) deficiency in shiverer myelin is expressed in shiverer reversible normal mouse chimaera nerves. Chimaera examined with immunocytochemical techniques have revealed populations of both densely labeled and unreacting myelinated Schwann cells. Single axons can innervate both Schwann cell types, demonstrating that the expression of P1 in Schwann cell myelin is unrelated to the shiverer or normal genotype of the neuron. The coexistence of both Schwann cell types in single nerves indicates that multiple progenitor Schwann cells are allocated to developing nerves and the mosaic patterns expressed further suggest that such cells tend to proliferate relatively small coherent clones of Schwann cells.
颤抖小鼠髓磷脂中髓磷脂碱性蛋白（P1）的缺乏在颤抖小鼠与正常小鼠的可逆嵌合神经中得以体现。采用免疫细胞化学技术检查的嵌合体显示，存在密集标记和无反应的有髓施万细胞群体。单个轴突可支配这两种施万细胞类型，这表明施万细胞髓磷脂中P1的表达与神经元的颤抖或正常基因型无关。单一神经中两种施万细胞类型的共存表明，多个祖代施万细胞被分配到发育中的神经，而所表现出的镶嵌模式进一步表明，这些细胞倾向于增殖形成相对较小的、连贯的施万细胞克隆。
