Piletz J E, Ganschow R E
Science. 1978 Jan 13;199(4325):181-3. doi: 10.1126/science.619449.
The inability of nursing pups to survive on milk of mice homozygous for the recessive mutation, lethal milk (lm), is correlated with a reduction in zinc levels of both milk and pup carcass. Administration of zinc to pups nursing on lmlm dams reduces the observed mortality and morbidity. It is suggested that lm alters zinc transport from maternal blood to milk and that its study may provide useful information for understanding the rare human disease, acrodermatitis enteropathica.
携带隐性致死突变基因（lm）的纯合子小鼠所产乳汁无法满足哺乳幼崽的生存需求，这与乳汁和幼崽尸体中锌含量的降低有关。给由携带lm基因的母鼠哺乳的幼崽补充锌，可以降低观察到的死亡率和发病率。研究表明，lm基因改变了锌从母体血液到乳汁的转运，对其进行研究可能为理解罕见的人类疾病——肠病性肢端皮炎提供有用信息。
