猫消化道中胃泌素和促胰液素的浓度。

Concentrations of gastrin and secretin in the alimentary tract of the cat.

作者信息

Miller T A, Llanos O L, Swierczek J S, Rayford P L, Thompson J C

出版信息

Surgery. 1978 Jan;83(1):90-3.

PMID:619477

Abstract

The distribution of gastrin and secretin in the alimentary tract of the cat was determined from the esophagogastric junction to the ileocecum. The total content and concentration of each of these hormones in mucosal extracts taken from the gastric fundus, gastric antrum, proximal and distal duodenum, proximal and distal jejunum, and ileum were measured with specific radioimmunoassays. The gastric antrum contained the highest concentration of gastrin, but appreciable amounts also were found in the duodenum. The highest concentrations of secretin were found in the duodenum, but impressive quantities were measured in the jejunum. The role of extra-antral gastrin and of those stores of secretin beyond the proximal duodenum (where the pH probably never falls to levels associated with release of secretin) currently are unknown.

摘要

从食管胃交界处到回盲部测定了猫消化道中胃泌素和促胰液素的分布。用特异性放射免疫分析法测定了从胃底、胃窦、十二指肠近端和远端、空肠近端和远端以及回肠获取的黏膜提取物中每种激素的总量和浓度。胃窦中胃泌素浓度最高，但十二指肠中也发现了相当数量的胃泌素。促胰液素浓度最高的部位是十二指肠，但空肠中的含量也可观。目前尚不清楚窦外胃泌素以及十二指肠近端以外的促胰液素储存部位（此处pH值可能从未降至与促胰液素释放相关的水平）的作用。