Weldon-Linne C M, Victor T A, Groothuis D R, Vick N A
Cancer. 1983 Dec 1;52(11):2055-63. doi: 10.1002/1097-0142(19831201)52:11<2055::aid-cncr2820521115>3.0.co;2-w.
In 1979, researchers described a series of young patients with clinically and histologically distinctive supratentorial gliomas which were designated pleomorphic (meningocerebral) xanthoastrocytomas (PXA). Significantly, patients with these neoplasms were reported to have a relatively favorable prognosis. The authors present a new case of PXA in a 32-year-old man. This case is unique for two reasons: (1) a relatively rapid fatal outcome with death 21 months after diagnosis; and (2) the presence, at autopsy, of extensive recurrent tumor with features of a malignant astrocytoma. Detailed electron microscopic and immunohistochemical studies, supporting the proposed subpial astrocytic origin of PXA, are presented. Literature pertaining to PXA is reviewed. This report illustrates the unique features of PXA and demonstrates its potential for aggressive behavior.
1979年，研究人员描述了一系列临床上和组织学上具有独特特征的幕上胶质瘤的年轻患者，这些肿瘤被命名为多形性（脑膜脑）黄色星形细胞瘤（PXA）。值得注意的是，据报道患有这些肿瘤的患者预后相对良好。作者报告了一名32岁男性的PXA新病例。该病例独特之处有两点：（1）诊断后21个月出现相对快速的致命结局；（2）尸检时发现广泛复发肿瘤，具有恶性星形细胞瘤的特征。本文展示了详细的电子显微镜和免疫组织化学研究结果，支持PXA起源于软膜下星形细胞的观点，并对与PXA相关的文献进行了综述。本报告阐述了PXA的独特特征，并证明了其具有侵袭性生长的可能性。
