Komiyama K, Umezawa I, Kuwano M, Komiyama S
Gan. 1983 Aug;74(4):602-6.
Antitumor activity of bleomycin against Ehrlich ascites carcinoma in mice was examined in the presence and absence of a polyene antibiotic, pimaricin. A single intraperitoneal (ip) injection of bleomycin and pimaricin in combination into tumor-bearing mice on day 1 produced a synergistic life-prolongation effect as compared with that of each agent alone. Accumulation of abdominal ascites was almost completely blocked by bleomycin in combination with the tetraene antibiotic. Frequent ip injection of small doses of bleomycin and pimaricin on day 1 produced a much greater increase in life span than the single ip injection. To obtain effective synergism under these treatment schedules, it appeared that the dose of bleomycin should be reciprocally proportional to the dose of pimaricin.
在有和没有多烯抗生素匹马霉素存在的情况下，检测了博来霉素对小鼠艾氏腹水癌的抗肿瘤活性。在第1天给荷瘤小鼠腹腔内单次注射博来霉素和匹马霉素的组合，与单独使用每种药物相比，产生了协同的延长寿命效果。博来霉素与四烯抗生素联合使用几乎完全阻止了腹腔腹水的积聚。在第1天频繁腹腔内注射小剂量的博来霉素和匹马霉素比单次腹腔内注射能使寿命延长更多。为了在这些治疗方案下获得有效的协同作用，似乎博来霉素的剂量应与匹马霉素的剂量成反比。
