Hood I C, Desa D J, Whyte R K
Hum Pathol. 1983 Nov;14(11):984-90. doi: 10.1016/s0046-8177(83)80178-6.
Fetal infection with Candida organisms has not commonly been reported. Umbilical cords and placentas from 23 cases of chorioamnionitis collected over a nine-year period were examined by electron microscopy and immunoperoxidase staining. Gross features, especially of the umbilical cord, were distinctive and included the pale yellow plaques pathognomonic of candidal funisitis. Histopathologically, the lesions were found to be focal and subamniotic and were often embedded in a "fibrinoid" exudate and surrounded by inflammatory cells. In some cases the exudate and inflammatory cells were deposited in dense bands. Immunoperoxidase staining showed the lesions to contain IgG, IgM, and IgA, which probably originated in dense-staining plasmacytoid and immunoblastic cells in the inflammatory infiltrates. Additional findings in two fetal cases of giant cell pneumonitis suggested that the fetus can mount a brisk inflammatory and immune response to Candida organisms as early as 18 weeks' gestation and that mucosal exposure to this antigen can result in production of IgA by the lung.
胎儿感染念珠菌属微生物的情况鲜有报道。对九年期间收集的23例绒毛膜羊膜炎病例的脐带和胎盘进行了电子显微镜检查和免疫过氧化物酶染色。大体特征，尤其是脐带的特征很独特，包括念珠菌性脐带炎特有的淡黄色斑块。组织病理学上，病变为局灶性且位于羊膜下，常包埋于“类纤维蛋白”渗出物中，并被炎性细胞包围。在某些病例中，渗出物和炎性细胞呈致密带状沉积。免疫过氧化物酶染色显示病变中含有IgG、IgM和IgA，这些可能源自炎性浸润中深染的浆细胞样细胞和免疫母细胞。两例胎儿巨细胞肺炎的其他发现表明，胎儿早在妊娠18周时就能对念珠菌属微生物产生强烈的炎性和免疫反应，且黏膜接触该抗原可导致肺部产生IgA。
