Starzl T E, Putnam C W
Int J Radiat Oncol Biol Phys. 1976 Sep-Oct;1(9-10):959-64. doi: 10.1016/0360-3016(76)90123-1.
Providing the anatomic conditions are appropriate, removal of as much as 85–90% of the liver is a relatively safe technique for the treatment of benign or malignant primary hepatic tumors and of isolated hepatic metastases. There have been apparent cures of malignant disease by this approach, but the paucity of concentrated experience at any one center and the failure so far to pool data from different centers effectively make a valid prognosis impossible. Total hepatectomy and liver replacement has resulted in the apparent core of some patients with primary hepatic malignancy. However, there has been an extremely high rate of recurrence of tumor. Small cancers which are lethal because of their strategic locations may provide an unusually good indication for liver replacement. Liver transplantation would rarely, if ever, be indicated for metastases to the liver.
如果解剖条件合适，切除多达85%至90%的肝脏对于治疗良性或恶性原发性肝肿瘤以及孤立性肝转移瘤来说是一种相对安全的技术。通过这种方法已经有恶性疾病明显治愈的案例，但由于任何一个中心集中经验的匮乏以及目前尚未能有效地汇总不同中心的数据，使得做出有效的预后判断变得不可能。全肝切除及肝脏置换已使一些原发性肝恶性肿瘤患者明显获益。然而，肿瘤复发率极高。因位置关键而致命的小癌肿可能为肝脏置换提供异常良好的指征。肝转移瘤极少（如果有的话）适合进行肝移植。
