霉菌三烯菌素和霉菌三烯醇对丝裂霉素C、6-巯基嘌呤、博来霉素、顺二氨二氯铂和5-氟尿嘧啶的增效作用。
Potentiation of mitomycin C, 6-mercaptopurine, bleomycin, cis-diamminedichloroplatinum and 5-fluorouracil by mycotrienins and mycotrienols.
作者信息
Kuwano M, Ikezaki K, Mamizuka K, Komiyama S, Seto H, Otake N, Sugita M, Yamaguchi T, Kishiye T, Fukawa H
出版信息
Gan. 1983 Oct;74(5):759-66.
Mycotrienins I and II and mycotrienols I and II are ansamycin antibiotics containing a triene structure, isolated from Streptomyces rishiriensis. An amphotericin B-resistant clone (AMBR-1) derived from cultured Chinese hamster V79 cells was cross-resistant to mycotrienins I and II, but not to mycotrienol I or II. These four ansamycin antibiotics were found to potentiate significantly the action of some anti-cancer agents including 5-fluorouracil, cis-diamminedichloroplatinum, bleomycin, mitomycin C and 6-mercaptopurine against cultured V79 cells. The action of adriamycin was not potentiated. These four ansamycin antibiotics showed a synergism spectrum similar to that of smaller polyene antibiotics.
霉菌三烯菌素I和II以及霉菌三烯醇I和II是含有三烯结构的安莎霉素类抗生素，从里氏链霉菌中分离得到。源自培养的中国仓鼠V79细胞的两性霉素B抗性克隆（AMBR-1）对霉菌三烯菌素I和II具有交叉抗性，但对霉菌三烯醇I或II没有抗性。发现这四种安莎霉素类抗生素能显著增强包括5-氟尿嘧啶、顺二氨二氯铂、博来霉素、丝裂霉素C和6-巯基嘌呤在内的一些抗癌药物对培养的V79细胞的作用。阿霉素的作用没有增强。这四种安莎霉素类抗生素显示出与较小的多烯类抗生素相似的协同作用谱。
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