Rosenthal I, Riesz P, Faraggi M
Int J Radiat Biol Relat Stud Phys Chem Med. 1983 Nov;44(5):463-8. doi: 10.1080/09553008314551451.
The technique of pulse radiolysis has been utilized to study the reactions of some aza analogues of nucleic acid components with hydrated electrons and OH radicals. The absorption spectra of the transient free radical adducts which result from these reactions and their decay kinetics were determined. The 5-aza analogues gave similar results to those of pyrimidine bases. The 6-aza analogues also showed similar kinetics, however, transient spectra were different. The presence of the sugar moiety in these aza analogues changed the rate law of the OH adduct transient decay from second order to first order kinetics. This finding may have implications for the understanding of the radiation chemistry of DNA.
脉冲辐解技术已被用于研究核酸成分的一些氮杂类似物与水合电子和羟基自由基的反应。测定了这些反应产生的瞬态自由基加合物的吸收光谱及其衰减动力学。5-氮杂类似物的结果与嘧啶碱基的结果相似。6-氮杂类似物也显示出相似的动力学，然而，瞬态光谱不同。这些氮杂类似物中糖部分的存在将羟基加合物瞬态衰减的速率定律从二级动力学变为一级动力学。这一发现可能对理解DNA的辐射化学有影响。
