前列腺素及其他血管活性物质对子宫血流和子宫肌层活性的影响。

The effect of prostaglandins and other vasoactive substances on uterine blood flow and myometrial activity.

作者信息

Still J G, Greiss F C

出版信息

Am J Obstet Gynecol. 1978 Jan 1;130(1):1-8. doi: 10.1016/0002-9378(78)90430-1.

PMID:619633

Abstract

The effects of prostaglandins (PG's), bradykinin, and adenosine on uterine blood flow (UBF) and intrauterine pressure (IUP) were investigated in conscious oophorectomized ewes. PGE1 and adenosine increased UBF to levels comparable to those induced by estradiol-17beta, whereas PGE2 and PGA1 achieved only 20 and 36 per cent of peak estradiol-induced levels, respectively. PGE1, PGE2, and adenosine all caused transient increases in IUP while PGA1 had no effect on myometrial activity. Bradykinin increased UBF to 60 per cent of peak estradiol-induced levels, with concomitant increases in IUP tonus. PGE2 and PGF2alpha decreased peak estrogen-induced UBF by 50 and 70 per cent, respectively, while inducing related increases in IUP. When compared with oxytocin, the effects of PGE2 at high flow appeared to be mediated only my myometrial activity, whereas PGF2alpha apparently caused vasoconstriction as well. These findings support the concept that PGE1 could play a role in mediating estrogen-induced uterine vasodilatation.

摘要

在清醒的去卵巢母羊中研究了前列腺素（PG）、缓激肽和腺苷对子宫血流量（UBF）和子宫内压（IUP）的影响。PGE1和腺苷使UBF增加至与17β-雌二醇诱导的水平相当，而PGE2和PGA1分别仅达到雌二醇诱导峰值水平的20%和36%。PGE1、PGE2和腺苷均引起IUP短暂升高，而PGA1对子宫肌层活动无影响。缓激肽使UBF增加至雌二醇诱导峰值水平的60%，同时IUP张力增加。PGE2和PGF2α分别使雌激素诱导的峰值UBF降低50%和70%，同时诱导IUP相关升高。与催产素相比，高流量时PGE2的作用似乎仅通过子宫肌层活动介导，而PGF2α显然也引起血管收缩。这些发现支持PGE1可能在介导雌激素诱导的子宫血管舒张中起作用这一概念。