Parkington H C, Lipton A
J Endocrinol. 1976 Aug;70(2):223-7. doi: 10.1677/joe.0.0700223.
Ovariectomized rats were given a single dose of synthetic oestrogen or progestogen, or both combined. On selected days after treatment one rat from each treatment group was killed and myometrical contractility in response to spasmogens was measured isometrically in isolated tissue baths. Contractility persisted at a low level after ovariectomy without steroid replacement (controls) for the 60 days of the experiment. The powerful potentiating action of oestrogen reached a maximum in about 10 days and sustained a high level thereafter. Progestogen treatment did not influence contractility to a significant degree when compared with saline, except that the contractions were sometimes of higher frequency and more irregular in size. There was a less powerful potentiating action on contractility with combined oestrogen and progestogen treatment than with oestrogen alone. It reached a maximum in 4 days and declined more rapidly than with oestrogen-treated preparation but was still vigorous for up to 30 days.
对去卵巢大鼠给予单剂量的合成雌激素或孕激素，或两者联合使用。在治疗后的选定日子，从每个治疗组中处死一只大鼠，并在离体组织浴中以等长方式测量子宫肌层对致痉剂的收缩性。在实验的60天里，去卵巢后未进行类固醇替代（对照组）的大鼠，其收缩性维持在较低水平。雌激素的强大增强作用在约10天达到最大值，此后维持在高水平。与生理盐水相比，孕激素治疗对收缩性没有显著影响，只是收缩有时频率更高且大小更不规则。雌激素和孕激素联合治疗对收缩性的增强作用不如单独使用雌激素时强。它在4天达到最大值，比雌激素处理的制剂下降得更快，但在长达30天内仍很强烈。
