Igisu K, Watanabe S, Shimosato Y, Kukita A
Jpn J Clin Oncol. 1983 Dec;13(4):693-702.
Twenty-four cases of mycosis fungoides and two cases of Sézary's syndrome were studied with special reference to the infiltration and proliferation of Langerhans cells stained with anti-S100 protein antibody. The number of S100+ histiocytes (Langerhans cells and their precursors) ranged from 104 to 345 (average 188) per 1,000 lymphoid cells in the erythematous and plaque stages, while it decreased to 4-71 (average 34) per 1,000 lymphoid cells in the tumor stage. Conversely, the number of lymphoid cells averaged 6 and 10 per S100+ histiocyte in the erythema and plaque stages, respectively, while it increased to 21.0 per S100+ histiocyte in the tumor stage. The mitotic index of lymphoid cells correlated with the lymphocyte/S100+ histiocyte ratio. A small number of S100+ histiocytes in mycosis fungoides indicated poor prognosis.
对24例蕈样肉芽肿和2例 Sézary 综合征进行了研究，特别关注用抗S100蛋白抗体染色的朗格汉斯细胞的浸润和增殖情况。在红斑期和斑块期，每1000个淋巴细胞中S100 + 组织细胞（朗格汉斯细胞及其前体）的数量为104至345个（平均188个），而在肿瘤期则降至每1000个淋巴细胞中4至71个（平均34个）。相反，在红斑期和斑块期，每一个S100 + 组织细胞中淋巴细胞的平均数分别为6个和10个，而在肿瘤期则增加到每一个S100 + 组织细胞中有21.0个。淋巴细胞的有丝分裂指数与淋巴细胞/S100 + 组织细胞比率相关。蕈样肉芽肿中少量的S100 + 组织细胞提示预后不良。
