阿贝尔逊鼠白血病病毒编码的酪氨酸特异性蛋白激酶的特性分析。
Characterization of the Abelson murine leukemia virus-encoded tyrosine-specific protein kinase.
作者信息
Wang J Y, Baltimore D
出版信息
Methods Enzymol. 1983;99:373-8. doi: 10.1016/0076-6879(83)99073-0.
PMID:6196601
Abstract
There is sufficient evidence that the A-MuL V protein is a tyrosine-specific protein kinase. There are methods for detecting this kinase activity and this kinase has been expressed in E. coli. Because the information coding for the tyrosine-specific protein kinase is present in normal mouse cells, such an enzyme must have a normal physiologic function. The elucidation of this physiologic function and the understanding of the role of this enzyme activity in neoplastic transformation is the challenge of the future.
摘要
有充分证据表明A-MuLV蛋白是一种酪氨酸特异性蛋白激酶。存在检测这种激酶活性的方法，并且这种激酶已在大肠杆菌中表达。由于编码酪氨酸特异性蛋白激酶的信息存在于正常小鼠细胞中，因此这种酶必定具有正常的生理功能。阐明这种生理功能以及了解这种酶活性在肿瘤转化中的作用是未来的挑战。
相似文献
1
Characterization of the Abelson murine leukemia virus-encoded tyrosine-specific protein kinase.阿贝尔逊鼠白血病病毒编码的酪氨酸特异性蛋白激酶的特性分析。
Methods Enzymol. 1983;99:373-8. doi: 10.1016/0076-6879(83)99073-0.
2
Evidence that the Abelson virus protein functions in vivo as a protein kinase that phosphorylates tyrosine.有证据表明，阿贝尔森病毒蛋白在体内作为一种使酪氨酸磷酸化的蛋白激酶发挥作用。
Proc Natl Acad Sci U S A. 1981 Mar;78(3):1552-6. doi: 10.1073/pnas.78.3.1552.
3
Purification and characterization of a protein-tyrosine kinase encoded by the Abelson murine leukemia virus.阿贝尔逊鼠白血病病毒编码的一种蛋白酪氨酸激酶的纯化与特性分析
J Biol Chem. 1985 Jul 5;260(13):8070-7.
4
Temperature-sensitive mutants of Abelson murine leukemia virus deficient in protein tyrosine kinase activity.缺乏蛋白酪氨酸激酶活性的阿贝尔逊鼠白血病病毒温度敏感突变体。
J Virol. 1990 Sep;64(9):4242-51. doi: 10.1128/JVI.64.9.4242-4251.1990.
5
Abelson-transformed fibroblasts contain nuclear phosphotyrosyl-proteins which preferentially bind to murine DNA.阿贝尔逊转化的成纤维细胞含有优先与小鼠DNA结合的核磷酸酪氨酸蛋白。
Nature. 1987;325(6104):552-4. doi: 10.1038/325552a0.
6
Possible target of Abelson virus phosphokinase in cell transformation.阿贝尔森病毒磷酸激酶在细胞转化中的可能靶点。
Experientia. 1986 Sep 15;42(9):1036-8. doi: 10.1007/BF01940721.
7
Purification of the receptor for epidermal growth factor from A-431 cells: its function as a tyrosyl kinase.从A-431细胞中纯化表皮生长因子受体：其作为酪氨酸激酶的功能。
Methods Enzymol. 1983;99:379-87. doi: 10.1016/0076-6879(83)99074-2.
8
A trans-acting protein kinase identified in cells transformed by Abelson murine leukemia virus.在阿贝尔森鼠白血病病毒转化的细胞中鉴定出的一种反式作用蛋白激酶。
Cold Spring Harb Symp Quant Biol. 1980;44 Pt 2,:855-7. doi: 10.1101/sqb.1980.044.01.091.
9
Different cellular substrates of Abelson leukemia virus transforming protein kinase in murine fibroblasts and lymphocytes.阿贝尔逊白血病病毒转化蛋白激酶在小鼠成纤维细胞和淋巴细胞中的不同细胞底物
Haematol Blood Transfus. 1985;29:298-301. doi: 10.1007/978-3-642-70385-0_61.
10
Phosphatidylinositol turnover and transformation of cells by Abelson murine leukaemia virus.
EMBO J. 1985 Dec 1;4(12):3173-8. doi: 10.1002/j.1460-2075.1985.tb04061.x.
引用本文的文献
1
Insertional mutagenesis of the Abelson murine leukemia virus genome: identification of mutants with altered kinase activity and defective transformation ability.阿贝尔逊鼠白血病病毒基因组的插入诱变：具有改变激酶活性和缺陷转化能力的突变体的鉴定。
J Virol. 1988 Mar;62(3):978-86. doi: 10.1128/JVI.62.3.978-986.1988.
Zotero 插件