ABVD方案治疗失败后，采用MOPP方案治疗难治性霍奇金淋巴瘤。
MOPP treatment of resistant Hodgkin's disease following ABVD failure.
作者信息
Cimino G, Anselmo A P, Marzullo A, Maurizi Enrici R, Mauro F, Papa G, Mandelli F
出版信息
Tumori. 1983 Oct 31;69(5):469-72. doi: 10.1177/030089168306900516.
PMID:6196891
Abstract
Fourteen patients with Hodgkin's disease resistant to ABVD were treated with MOPP chemotherapy (nitrogen mustard, vincristine, procarbazine, prednisone). Complete remission was obtained in 6 patients (43%). Four of the 6 complete responders are disease free after 5, 20, 23, 35 months. The actuarial median survival after MOPP of all patients is 20 months. These data confirm that there is no "cross-resistance" among the drugs included in the two schedules.
摘要
14例对ABVD耐药的霍奇金病患者接受了MOPP化疗（氮芥、长春新碱、丙卡巴肼、泼尼松）。6例患者（43%）获得完全缓解。6例完全缓解者中有4例在5、20、23、35个月后无疾病。所有患者MOPP治疗后的精算中位生存期为20个月。这些数据证实这两种化疗方案中的药物之间不存在“交叉耐药”。
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