Wittekind C, Wichmann T, Von Kleist S
Anticancer Res. 1983 Sep-Oct;3(5):327-30.
Sixty seven germ cell tumors were studied for the presence of AFP and HCG by an immunoperoxidase technique. In the tumor tissues of 30 patients with seminomas no AFP-positivity was found, and in one case HCG positive giant cells were seen. In nonseminomatous tumors 54% were AFP-positive and 51% were HCG-positive. HCG was localized in syncytiotrophoblastic-like giant cells, occurring in choriocarcinomatous elements and as single cells in embryonal carcinomas, teratocarcinomas, and yolk sac tumors. AFP was demonstrable in 12 endodermal sinus tumor elements and, additionally, in solid cell clusters in embryonal carcinoma areas, arising as a component of a mixed germ cell tumor. In pure embryonal carcinomas we could not detect any positivity for either of the markers.
采用免疫过氧化物酶技术对67例生殖细胞肿瘤进行甲胎蛋白（AFP）和人绒毛膜促性腺激素（HCG）检测。在30例精原细胞瘤患者的肿瘤组织中，未发现AFP阳性，仅1例可见HCG阳性巨细胞。在非精原细胞瘤中，54%为AFP阳性，51%为HCG阳性。HCG定位于合体滋养层样巨细胞，见于绒毛膜癌成分，也可见于胚胎癌、畸胎癌和卵黄囊瘤中的单个细胞。在12个内胚窦瘤成分中可检测到AFP，此外，在胚胎癌区域的实性细胞团中也可检测到AFP，这些区域是混合性生殖细胞肿瘤的一部分。在单纯胚胎癌中，两种标志物均未检测到阳性。
