[单克隆抗体的抗病毒作用]

[Antiviral action of monoclonal antibodies].

作者信息

Novokhatskiĭ A S, Gaĭdamovich S Ia, Kushch A A, Mel'nikova E E, Tkachenko A V

出版信息

Vopr Virusol. 1983 Sep-Oct;28(5):567-70.

Abstract

The antiviral effect of monoclonal antibodies MAK-14-7 possessing the neutralizing activity was studied on the model of Venezuelan equine encephalomyelitis virus in cell cultures and in experimentally infected laboratory animals. Mouse monoclonal antibodies exerted a marked specific antiviral effect in tissue culture and in white mice inhibiting virus reproduction by 1-3-5 log PFU/ml. The degree of inhibition of virus reproduction is inversely proportional to the multiplicity of infection. When used in combination with remantadine, ribavirin, interferon, and its inducer poly (I) X poly (C), the monoclonal antibodies MAK-14-7 exerted additive antiviral effect.

摘要

对具有中和活性的单克隆抗体MAK-14-7在细胞培养物和实验感染的实验动物模型上，研究了其对委内瑞拉马脑炎病毒的抗病毒作用。小鼠单克隆抗体在组织培养物和小白鼠中表现出显著的特异性抗病毒作用，可使病毒繁殖抑制1-3-5 log PFU/ml。病毒繁殖的抑制程度与感染复数成反比。当与金刚烷胺、利巴韦林、干扰素及其诱导剂聚肌苷酸-聚胞苷酸联合使用时，单克隆抗体MAK-14-7发挥相加抗病毒作用。

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