Sawyer R H, O'Guin W M, Knapp L W
Dev Biol. 1984 Jan;101(1):8-18. doi: 10.1016/0012-1606(84)90111-8.
Epidermal-dermal tissue interactions regulate morphogenesis and tissue-specific keratinization of avian skin appendages. The morphogenesis of scutate scales differs from that of reticulate scales, and the keratin polypeptides of their epidermal surfaces are also different. Do the inductive cues which initiate morphogenesis of these scales also establish the tissue-specific keratin patterns of the epidermis, or does the control of tissue-specific keratinization occur at later stages of development? Unlike feathers, scutate and reticulate scales can be easily separated into their epidermal and dermal components late in development when the major events of morphogenesis have been completed and keratinization will begin. Using a common responding tissue (chorionic epithelium) in combination with scutate and reticulate scale dermises, we find that these embryonic dermises, which have completed morphogeneis, can direct tissue-specific stratification and keratinization. In other words, once a scale dermis has acquired its form, through normal morphogenesis, it is no longer able to initiate morphogenesis of that scale, but it can direct tissue-specific stratification and keratinization of a foreign ectodermal epithelium, which itself has not undergone scale morphogenesis.
表皮-真皮组织相互作用调节鸟类皮肤附属器的形态发生和组织特异性角质化。盾鳞的形态发生与网鳞不同，其表皮表面的角蛋白多肽也不同。启动这些鳞片形态发生的诱导信号是否也建立了表皮的组织特异性角蛋白模式，或者组织特异性角质化的控制是否发生在发育的后期阶段？与羽毛不同，盾鳞和网鳞在发育后期很容易分离成它们的表皮和真皮成分，此时形态发生的主要事件已经完成，角质化即将开始。通过使用一种共同的反应组织（绒毛膜上皮）与盾鳞和网鳞真皮相结合，我们发现这些已经完成形态发生的胚胎真皮能够指导组织特异性分层和角质化。换句话说，一旦鳞片真皮通过正常形态发生获得其形态，它就不再能够启动该鳞片的形态发生，但它可以指导未经历鳞片形态发生的外来外胚层上皮的组织特异性分层和角质化。
