Maeyama M, Tayama C, Inoue S, Tajima C, Onizuka Y, Tanaka N, Nakayama M, Iwamasa T
Gynecol Oncol. 1984 Jan;17(1):104-16. doi: 10.1016/0090-8258(84)90064-7.
Serial serum determinations of alpha-fetoprotein (alpha FP) as a tumor marker were carried out in the management of six patients with endodermal sinus tumor (EST). Histological examinations in all six patients revealed a typical EST pattern, and in one of them another germ cell tumor, a malignant teratoma, was also found. All patients were treated postoperatively with combination chemotherapy. The serum alpha FP concentrations before treatment, using radioimmunoassay, were abnormally high and ranged from 2500 to 100,000 ng/ml. One patient having Stage Ia neoplasm is living at 50 months after diagnosis with a normal alpha FP concentration and without clinical evidence of recurrence. The other five patients with Stage III disease died from 4 to 9 months after surgery, respectively, although the serum alpha FP in all these cases during chemotherapy decreased markedly but temporarily to a normal level (less than 20 ng/ml) or to 3000 ng/ml and was paralleled by a certain improvement in the conditions of the disease. These results suggest that serial serum determination of alpha FP may be useful as a marker and prognostic indicator of endodermal sinus tumor.
作为肿瘤标志物，对6例内胚窦瘤（EST）患者进行了甲胎蛋白（αFP）的系列血清测定。所有6例患者的组织学检查均显示典型的EST模式，其中1例还发现了另一种生殖细胞肿瘤——恶性畸胎瘤。所有患者术后均接受联合化疗。采用放射免疫分析法测定，治疗前血清αFP浓度异常升高，范围为2500至100,000 ng/ml。1例Ia期肿瘤患者在诊断后50个月仍存活，αFP浓度正常，无复发的临床证据。其他5例III期疾病患者分别在术后4至9个月死亡，尽管所有这些病例在化疗期间血清αFP均显著但暂时降至正常水平（低于20 ng/ml）或降至3000 ng/ml，且疾病状况有一定改善。这些结果表明，系列血清甲胎蛋白测定可能作为内胚窦瘤的标志物和预后指标。
