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[利用人HLA血清吸收法检测HLA抗原A2和B17的共同决定簇]

[Detection of common determinants of HLA antigens A2 and B17 by absorption using human HLA serum].

作者信息

Májský A, Korínková P

出版信息

Folia Haematol Int Mag Klin Morphol Blutforsch. 1983;110(5):768-72.

PMID:6198261
Abstract

Attempts of cross absorption where sera of anti-HLA A2 + B17, anti-HLA A2 and anti-HLA B17 with thrombocytes were absorbed from donors of HLA A2 positive, B17 negative and HLA A2 negative, B17 positive, revealed that anti-HLA A2 and anti-HLA B17 could be eliminated from the sera of both HLA types on the platelets. Thus, the findings allow the existence of a common determinant of HLA A2 and B17-antigens to be assumed. This is the first case where the evidence of a cross reaction between antigens of two different HLA loci with human sera could be established.

摘要

采用血小板对HLA A2阳性、B17阴性及HLA A2阴性、B17阳性供体的抗HLA A2 + B17、抗HLA A2和抗HLA B17血清进行交叉吸收试验,结果显示,抗HLA A2和抗HLA B17可从两种HLA类型供体血清与血小板的反应中消除。因此,研究结果提示HLA A2和B17抗原可能存在共同决定簇。这是首次证实两种不同HLA位点抗原与人血清之间存在交叉反应。

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A serological study of the HLA-B17 cross-reactive group.
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