Bodner L, Kuyatt B L, Hand A R, Baum B J
Radiat Res. 1984 Feb;97(2):386-95.
The effect of X irradiation on rat parotid acinar cell function was evaluated in vitro 1, 3, and 7 days following in vivo exposure to 2000 R. Several cellular functions were followed: protein secretion (amylase release), ion movement (K+ efflux and reuptake), amino acid transport (alpha-amino[14C]isobutyric acid), and an intermediary metabolic response ( [14C]glucose oxidation). In addition both the morphologic appearance and in vivo saliva secretory ability of parotid cells were assessed. Our results demonstrate that surviving rat parotid acinar cells, isolated and studied in vitro 1-7 days following 2000 R, remain functionally intact despite in vivo diminution of secretory function.
在对大鼠进行2000伦琴的体内照射后1天、3天和7天，在体外评估了X射线照射对大鼠腮腺腺泡细胞功能的影响。监测了几种细胞功能：蛋白质分泌（淀粉酶释放）、离子移动（钾离子外流和再摄取）、氨基酸转运（α-氨基[¹⁴C]异丁酸）以及中间代谢反应（[¹⁴C]葡萄糖氧化）。此外，还评估了腮腺细胞的形态外观和体内唾液分泌能力。我们的结果表明，在接受2000伦琴照射后1至7天分离并在体外研究的存活大鼠腮腺腺泡细胞，尽管其体内分泌功能有所降低，但在功能上仍保持完整。
