Mechanism of action of the nitrosoureas--1. Role of fluoroethylcytidine in the reaction of bis-fluoroethyl nitrosourea with nucleic acids. - Suppr | 超能文献

Mechanism of action of the nitrosoureas--1. Role of fluoroethylcytidine in the reaction of bis-fluoroethyl nitrosourea with nucleic acids.

作者信息

Tong W P, Ludlum D B

出版信息

Biochem Pharmacol. 1978 Jan 1;27(1):77-81. doi: 10.1016/0006-2952(78)90259-9.

DOI:10.1016/0006-2952(78)90259-9

Abstract

摘要

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Mechanism of action of the nitrosoureas: formation of 1,2-(diguanosin-7-yl) ethane from the reaction of BCNU (1,3-bis-[2-chloroethyl]-1-nitrosourea) with guanosine.亚硝基脲类的作用机制：BCNU（1,3-双-[2-氯乙基]-1-亚硝基脲）与鸟苷反应生成1,2-（二鸟苷-7-基）乙烷。

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O2-alkylcytidine--a new major product of neutral, aqueous reaction of cytidine with carcinogens.O2-烷基胞苷——胞苷与致癌物在中性水溶液反应中产生的一种新的主要产物。

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Evaluation of the alkylating activity of nitrosoureas by thin-layer densitometry.通过薄层光密度法评估亚硝基脲的烷基化活性。

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Biochemical and pharmacologic properties of nitrosoureas.

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Synthesis of polynucleotides which contain 3,N4-ethanocytidine, a nucleoside modification resulting from the action of bis(chloroethyl)-nitrosourea.包含3,N4-乙撑胞苷的多核苷酸的合成，3,N4-乙撑胞苷是一种由双（氯乙基）亚硝基脲作用产生的核苷修饰产物。

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