Ades E W, Hinson A
J Clin Lab Immunol. 1983 Aug;11(4):173-6.
Little is known at present about the nature of the natural killer (NK) cell-tumor target cell interaction. Human NK cells recognize multiple target antigens. The ligands (antigens) involved in this interaction have not been identified. Previously, we have shown that some monosaccharides inhibit NK cytolysis in a dose-dependent fashion and that NK cell activity involves recognition of carbohydrate structures on target cells via receptors on the effector cell surface. Using human interferon, we have found that monosaccharides inhibit interferon enhanced NK functional activity in a dose-dependent fashion. In addition, we demonstrate that glycosidase treatment of effector cells results in complete inhibition of NK activity.
目前对于自然杀伤（NK）细胞与肿瘤靶细胞相互作用的本质了解甚少。人类NK细胞可识别多种靶抗原。参与这种相互作用的配体（抗原）尚未得到鉴定。此前，我们已经表明一些单糖以剂量依赖的方式抑制NK细胞溶解作用，并且NK细胞活性涉及通过效应细胞表面的受体识别靶细胞上的碳水化合物结构。利用人类干扰素，我们发现单糖以剂量依赖的方式抑制干扰素增强的NK功能活性。此外，我们证明对效应细胞进行糖苷酶处理会导致NK活性完全受到抑制。
