Nakamura K, Hagiwara M, Aikawa A, Deguchi N, Tazaki H, Takeshita E, Ito S
Gan No Rinsho. 1983 Dec;29(15):1779-82.
A 52 year-old male with advanced testicular seminoma (stage II N4) underwent right radical orchiectomy, followed by chemotherapy with vinblastine, bleomycin and cis-platinum. This resulted a partial response and he was well for 24 months after the operation. Serial monitoring of serum HCG and HCG-beta has been done, using three kinds of double antibody radioimmunoassays. A substance with immunological similarity to free HCG-beta was detected in sera and tumor extract. The serum level of this substance was reduced in parallel with the cytoreduction of metastasis by chemotherapy. A rational therapeutic approach to advanced seminoma and its serum marker are discussed briefly.
