Maccarrone C, Malta E, Raper C
J Cardiovasc Pharmacol. 1984 Jan-Feb;6(1):132-41.
We compared the beta-adrenoceptor stimulant actions of dobutamine and (-)-isoprenaline in isolated tissue preparations (atria, trachea, and uterus) from the guinea pig and in chloralose-anaesthetized, vagotomized cats (arterial blood pressure, heart rate, hindlimb perfusion pressure, and soleus muscle contractility). The results obtained in these experiments indicate that, on a dose basis, dobutamine shows little selectivity in producing alpha-, beta 1-, and beta 2-adrenoceptor-mediated effects. In phentolamine-treated cats, reductions in arterial pressure and total peripheral resistance produced by infusions of dobutamine were little affected by the beta 2-adrenoceptor-selective antagonist butoxamine, but were antagonized by atenolol. The rise in cardiac output produced by dobutamine involved increases in both heart rate and stroke volume. There was little indication of a selective inotropic action, a feature that confirmed the results obtained in isolated atrial preparations. The increase in cardiac output appeared to involve both alpha- and beta-receptor-mediated actions, because phentolamine reduced the rise in cardiac output by reducing stroke volume.
我们比较了多巴酚丁胺和（-）-异丙肾上腺素对豚鼠离体组织标本（心房、气管和子宫）以及水合氯醛麻醉、迷走神经切断的猫（动脉血压、心率、后肢灌注压和比目鱼肌收缩力）的β-肾上腺素能受体刺激作用。这些实验所得结果表明，基于剂量而言，多巴酚丁胺在产生α-、β1-和β2-肾上腺素能受体介导的效应方面几乎没有选择性。在酚妥拉明处理的猫中，输注多巴酚丁胺所引起的动脉压和总外周阻力降低，几乎不受β2-肾上腺素能受体选择性拮抗剂布托沙明的影响，但被阿替洛尔拮抗。多巴酚丁胺所引起的心输出量增加涉及心率和每搏量的增加。几乎没有选择性变力作用的迹象，这一特征证实了在离体心房标本中获得的结果。心输出量的增加似乎涉及α-和β-受体介导的作用，因为酚妥拉明通过降低每搏量减少了心输出量的增加。
