植入部位对Walker 256癌大鼠转移灶增殖的影响。
Influence of lodgement site on the proliferation of metastases of Walker 256 carcinoma in the rat.
作者信息
Bellamy D, Hinsull S M
出版信息
Br J Cancer. 1978 Jan;37(1):81-5. doi: 10.1038/bjc.1978.12.
Abstract
The growth of s.c. Walker 256 carcinoma was found to be independent of secondary growths induced by i.v. injection. Tumour cells injected i.v. lodged mainly in the lungs, with small clusters of cells in the lymph nodes. The rate of cellular proliferation of these secondary growths of Walker carcinoma was significantly higher than that observed in the s.c. tumour. In addition, host lung tissue was found to inhibit the development of metastases, and it is postulated that the host tissue may produce a diffusible inhibitor and that differences in the effectiveness of these humoral factors may account, in part, for locational differences in tumour growth patterns.
摘要
发现皮下接种的Walker 256癌的生长与静脉注射诱导的继发性生长无关。静脉注射的肿瘤细胞主要滞留在肺部，淋巴结中有小细胞簇。Walker癌这些继发性生长的细胞增殖率明显高于皮下肿瘤中观察到的增殖率。此外，发现宿主肺组织可抑制转移的发生，据推测宿主组织可能产生一种可扩散的抑制剂，这些体液因子有效性的差异可能部分解释了肿瘤生长模式的位置差异。
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