Dorobek W, Misiorowski W, Niewiadomska A, Baranowska B, Kuzaka B, Krzeski T, Zgliczyński S
Nuklearmedizin. 1983 Dec;22(6):309-13.
The aim of this study was to develop a technique for the radioimmunological determination of the activity of LH-like substances in the human prostate. The material comprised 19 specimens of prostatic tissue obtained during transbladder extirpation in patients with benign prostatic hyperplasia. Tissues of human testes and human sceletal muscle were used as controls. The method adopted for LH extraction from the membrane fraction of human prostatic tissue appeared to be sufficiently specific, accurate and sensitive for routine laboratory investigations. The concentrations of the LH-like immunoreactivity in human testicular tissue was found to be 57, 46 and 70 mU per g of the membrane fraction while those of the prostatic gland tissues ranged from 34 to 155 mU per g of the membrane fraction. However such LH-like substance was not found in human sceletal muscle tissue. It seems that the LH-type activity is an indirect proof for the existence of LH receptors in the human prostate.
本研究的目的是开发一种用于放射免疫测定人前列腺中促黄体生成素（LH）样物质活性的技术。材料包括19例良性前列腺增生患者经膀胱摘除术获取的前列腺组织标本。用人睾丸组织和人骨骼肌组织作为对照。从人前列腺组织膜部分提取LH所采用的方法对于常规实验室研究而言似乎具有足够的特异性、准确性和敏感性。发现人睾丸组织中LH样免疫反应性的浓度为每克膜部分57、46和70 mU，而前列腺组织的浓度范围为每克膜部分34至155 mU。然而，在人骨骼肌组织中未发现此类LH样物质。看来LH型活性是人类前列腺中存在LH受体的间接证据。
